<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:01a0c545-4f8a-7301-a0cf-c820f2ffd4e5,g:faa155c5-e64d-4052-b00d-5b3130b67e82-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.colgate.com/role/CoverPage" xlink:type="simple" xlink:href="cl-20260930.xsd#CoverPage"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_01a0c545-5118-7ba3-affb-b79b8df7a6f5" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntitiesTable_01a0c545-5118-7ba3-affb-b79b8df7a6f5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_01a0c545-5118-7464-8d59-372ab71698c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_dei_EntitiesTable_01a0c545-5118-7ba3-affb-b79b8df7a6f5" xlink:to="loc_us-gaap_StatementClassOfStockAxis_01a0c545-5118-7464-8d59-372ab71698c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7464-8d59-372ab71698c2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementClassOfStockAxis_01a0c545-5118-7464-8d59-372ab71698c2" xlink:to="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7464-8d59-372ab71698c2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7dd5-bc8b-bd557017701a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ClassOfStockDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementClassOfStockAxis_01a0c545-5118-7464-8d59-372ab71698c2" xlink:to="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7dd5-bc8b-bd557017701a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_01a0c545-5118-7341-b7c1-5bb67207e7d6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7dd5-bc8b-bd557017701a" xlink:to="loc_us-gaap_CommonStockMember_01a0c545-5118-7341-b7c1-5bb67207e7d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A0300NotesDue2029Member_01a0c545-5118-7c79-af23-d9e8d868d72b" xlink:href="cl-20260930.xsd#cl_A0300NotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7dd5-bc8b-bd557017701a" xlink:to="loc_cl_A0300NotesDue2029Member_01a0c545-5118-7c79-af23-d9e8d868d72b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A1.375NotesDue2034Member_01a0c545-5118-7873-b64e-a36d83b2a51e" xlink:href="cl-20260930.xsd#cl_A1.375NotesDue2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7dd5-bc8b-bd557017701a" xlink:to="loc_cl_A1.375NotesDue2034Member_01a0c545-5118-7873-b64e-a36d83b2a51e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A3.250NotesDue2035Member_01a0c545-5118-7799-bb01-91a86f2af2f3" xlink:href="cl-20260930.xsd#cl_A3.250NotesDue2035Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7dd5-bc8b-bd557017701a" xlink:to="loc_cl_A3.250NotesDue2035Member_01a0c545-5118-7799-bb01-91a86f2af2f3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_A0.875Notesdue2039Member_01a0c545-5118-7285-8caa-ea43834556c9" xlink:href="cl-20260930.xsd#cl_A0.875Notesdue2039Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockDomain_01a0c545-5118-7dd5-bc8b-bd557017701a" xlink:to="loc_cl_A0.875Notesdue2039Member_01a0c545-5118-7285-8caa-ea43834556c9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_01a0c545-5118-7504-a775-4fb40a23aea9" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentType"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_DocumentType_01a0c545-5118-7504-a775-4fb40a23aea9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_01a0c545-5118-7a5f-9663-bec7b6eff5c6" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentQuarterlyReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_DocumentQuarterlyReport_01a0c545-5118-7a5f-9663-bec7b6eff5c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_01a0c545-5118-78d1-88ac-bdf0aac26225" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentPeriodEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_DocumentPeriodEndDate_01a0c545-5118-78d1-88ac-bdf0aac26225" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_01a0c545-5118-712a-a3ce-602d6c28cfe7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentTransitionReport"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_DocumentTransitionReport_01a0c545-5118-712a-a3ce-602d6c28cfe7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_01a0c545-5118-7bd7-b35c-a825cf808a83" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFileNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityFileNumber_01a0c545-5118-7bd7-b35c-a825cf808a83" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_01a0c545-5118-7077-b72f-ab9f69053472" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityRegistrantName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityRegistrantName_01a0c545-5118-7077-b72f-ab9f69053472" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_01a0c545-5118-7bba-9652-e22989fc487e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityIncorporationStateCountryCode_01a0c545-5118-7bba-9652-e22989fc487e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_01a0c545-5118-72e3-82b8-57b3b6a66994" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityTaxIdentificationNumber_01a0c545-5118-72e3-82b8-57b3b6a66994" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_01a0c545-5118-737d-80b8-10a344f3fddc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressAddressLine1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityAddressAddressLine1_01a0c545-5118-737d-80b8-10a344f3fddc" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_01a0c545-5118-7923-9c11-ad85e2512145" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressCityOrTown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityAddressCityOrTown_01a0c545-5118-7923-9c11-ad85e2512145" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_01a0c545-5118-7c79-a044-81ee0a0e8daf" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressStateOrProvince"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityAddressStateOrProvince_01a0c545-5118-7c79-a044-81ee0a0e8daf" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_01a0c545-5118-7f75-af5a-569dc1aa4b3a" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityAddressPostalZipCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityAddressPostalZipCode_01a0c545-5118-7f75-af5a-569dc1aa4b3a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_01a0c545-5118-7dc9-9e29-84e486533722" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CityAreaCode"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_CityAreaCode_01a0c545-5118-7dc9-9e29-84e486533722" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_01a0c545-5118-7de2-be05-52a20d834d16" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_LocalPhoneNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_LocalPhoneNumber_01a0c545-5118-7de2-be05-52a20d834d16" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_01a0c545-5118-73e1-801d-c41358abed1e" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_Security12bTitle"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_Security12bTitle_01a0c545-5118-73e1-801d-c41358abed1e" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_01a0c545-51c7-759b-8679-9bb0861fe1a4" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_TradingSymbol"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_TradingSymbol_01a0c545-51c7-759b-8679-9bb0861fe1a4" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_01a0c545-51c7-7217-aa17-1ed414014ecf" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_SecurityExchangeName"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_SecurityExchangeName_01a0c545-51c7-7217-aa17-1ed414014ecf" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_01a0c545-51c7-72b2-aec0-1dca161fb841" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCurrentReportingStatus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityCurrentReportingStatus_01a0c545-51c7-72b2-aec0-1dca161fb841" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_01a0c545-51c7-708b-a594-520900b3bab1" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityInteractiveDataCurrent_01a0c545-51c7-708b-a594-520900b3bab1" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_01a0c545-51c7-7648-a533-c51b793d43b2" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityFilerCategory"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityFilerCategory_01a0c545-51c7-7648-a533-c51b793d43b2" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_01a0c545-51c7-7b59-888c-2dc786cc2feb" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntitySmallBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntitySmallBusiness_01a0c545-51c7-7b59-888c-2dc786cc2feb" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_01a0c545-51c7-7c5e-b000-814963b7aecc" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityEmergingGrowthCompany_01a0c545-51c7-7c5e-b000-814963b7aecc" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_01a0c545-51c7-7622-ab30-1c600ffa3abe" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityShellCompany"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityShellCompany_01a0c545-51c7-7622-ab30-1c600ffa3abe" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_01a0c545-51c7-7dcb-8e41-8f582ccb9e13" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_01a0c545-51c7-7dcb-8e41-8f582ccb9e13" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_01a0c545-51c7-7595-ac09-49ef65f8d222" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_EntityCentralIndexKey"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_EntityCentralIndexKey_01a0c545-51c7-7595-ac09-49ef65f8d222" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_01a0c545-51c7-7a7a-b80e-6a776da3eed7" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_CurrentFiscalYearEndDate_01a0c545-51c7-7a7a-b80e-6a776da3eed7" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_01a0c545-51c7-7e9c-836e-2284713f3a24" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalYearFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_DocumentFiscalYearFocus_01a0c545-51c7-7e9c-836e-2284713f3a24" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_01a0c545-51c7-7cd5-93ab-8b388be1cf1d" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_DocumentFiscalPeriodFocus_01a0c545-51c7-7cd5-93ab-8b388be1cf1d" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_01a0c545-51c7-7fa7-b15f-06579141049b" xlink:href="https://xbrl.sec.gov/dei/2026/dei-2026.xsd#dei_AmendmentFlag"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityInformationLineItems_01a0c545-5118-76f2-ac16-21f1b0d636f0" xlink:to="loc_dei_AmendmentFlag_01a0c545-51c7-7fa7-b15f-06579141049b" xlink:type="arc" order="28"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/CondensedConsolidatedStatementsofChangesinShareholdersEquity" xlink:type="simple" xlink:href="cl-20260930.xsd#CondensedConsolidatedStatementsofChangesinShareholdersEquity"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/CondensedConsolidatedStatementsofChangesinShareholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_01a0c545-51c8-7ab6-9751-6641ed1f6cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_01a0c545-51c8-7591-9d3e-b1e6c0e8b168" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_01a0c545-51c8-7ab6-9751-6641ed1f6cb3" xlink:to="loc_us-gaap_StatementTable_01a0c545-51c8-7591-9d3e-b1e6c0e8b168" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-752b-af2d-d8e4a4f6af97" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_01a0c545-51c8-7591-9d3e-b1e6c0e8b168" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-752b-af2d-d8e4a4f6af97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-752b-af2d-d8e4a4f6af97_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-752b-af2d-d8e4a4f6af97" xlink:to="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-752b-af2d-d8e4a4f6af97_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-752b-af2d-d8e4a4f6af97" xlink:to="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_01a0c545-51c8-74b3-936a-4f7cebfaf506" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:to="loc_us-gaap_CommonStockMember_01a0c545-51c8-74b3-936a-4f7cebfaf506" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_01a0c545-51c8-7c5f-9b6a-92d035f5d388" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_01a0c545-51c8-7c5f-9b6a-92d035f5d388" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_01a0c545-51c8-7eef-b7f8-eaefb5f180aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:to="loc_us-gaap_TreasuryStockCommonMember_01a0c545-51c8-7eef-b7f8-eaefb5f180aa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_01a0c545-51c8-7098-b824-af16b1229d08" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:to="loc_us-gaap_RetainedEarningsMember_01a0c545-51c8-7098-b824-af16b1229d08" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a0c545-51c8-7e2d-bd91-98afbf9a7ef5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a0c545-51c8-7e2d-bd91-98afbf9a7ef5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_01a0c545-51c8-761c-92ba-518944bad9a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7e21-afc4-e059e08cd7f2" xlink:to="loc_us-gaap_NoncontrollingInterestMember_01a0c545-51c8-761c-92ba-518944bad9a0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_01a0c545-51c8-7ab6-9751-6641ed1f6cb3" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_01a0c545-51c8-7843-87dc-005573cae5a3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_01a0c545-51c8-7843-87dc-005573cae5a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_01a0c545-51c8-76b5-b0fc-bac94f7a80c2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_ProfitLoss_01a0c545-51c8-76b5-b0fc-bac94f7a80c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_01a0c545-51c8-7c1c-b712-bc6686aa9fe7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_01a0c545-51c8-7c1c-b712-bc6686aa9fe7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStock_01a0c545-51c8-7921-bf7b-33149b255ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DividendsCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_DividendsCommonStock_01a0c545-51c8-7921-bf7b-33149b255ffc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_01a0c545-51c8-7551-9f6d-9465f881b7e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_01a0c545-51c8-7551-9f6d-9465f881b7e8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_01a0c545-51c8-7d5d-8510-45c8f5504578" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_01a0c545-51c8-7d5d-8510-45c8f5504578" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_01a0c545-51c8-7333-8e72-a545a2bd96cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures_01a0c545-51c8-7333-8e72-a545a2bd96cf" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_01a0c545-51c8-7e68-97d5-ac155e755fb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_01a0c545-51c8-7e68-97d5-ac155e755fb0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityOther_01a0c545-51c8-709d-afdc-0427fd3ffc2c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_01a0c545-51c8-73d1-bea1-61b40bba8181" xlink:to="loc_us-gaap_StockholdersEquityOther_01a0c545-51c8-709d-afdc-0427fd3ffc2c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_01a0c545-51c8-7cce-b9a5-1b8d04bf10cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7e51-91c8-9a65e1df9b92" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_01a0c545-51c8-77fd-a882-2195acfee813" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7e51-91c8-9a65e1df9b92" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_01a0c545-51c8-77fd-a882-2195acfee813" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-7f84-a985-62ccd5aba189" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_01a0c545-51c8-77fd-a882-2195acfee813" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-7f84-a985-62ccd5aba189" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-7f84-a985-62ccd5aba189_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-7f84-a985-62ccd5aba189" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-7f84-a985-62ccd5aba189_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-72cf-a02e-58f7e63fb0fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-7f84-a985-62ccd5aba189" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-72cf-a02e-58f7e63fb0fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_CareTopCoPtyLtdMember_01a0c545-51c8-7d3e-96a7-3b0c5a204648" xlink:href="cl-20260930.xsd#cl_CareTopCoPtyLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-72cf-a02e-58f7e63fb0fb" xlink:to="loc_cl_CareTopCoPtyLtdMember_01a0c545-51c8-7d3e-96a7-3b0c5a204648" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_01a0c545-51c8-74e4-b073-0b9e33645180" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_01a0c545-51c8-77fd-a882-2195acfee813" xlink:to="loc_srt_RangeAxis_01a0c545-51c8-74e4-b073-0b9e33645180" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a0c545-51c8-74e4-b073-0b9e33645180_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_01a0c545-51c8-74e4-b073-0b9e33645180" xlink:to="loc_srt_RangeMember_01a0c545-51c8-74e4-b073-0b9e33645180_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a0c545-51c8-7c1b-9222-ef5f1d44d958" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_01a0c545-51c8-74e4-b073-0b9e33645180" xlink:to="loc_srt_RangeMember_01a0c545-51c8-7c1b-9222-ef5f1d44d958" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_01a0c545-51c8-72d7-b8a6-09983ff04223" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a0c545-51c8-7c1b-9222-ef5f1d44d958" xlink:to="loc_srt_MinimumMember_01a0c545-51c8-72d7-b8a6-09983ff04223" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_01a0c545-51c8-7d55-8996-99c46280f425" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a0c545-51c8-7c1b-9222-ef5f1d44d958" xlink:to="loc_srt_MaximumMember_01a0c545-51c8-7d55-8996-99c46280f425" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a0c545-51c8-72f8-a89f-6d783a1f6577" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7e51-91c8-9a65e1df9b92" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a0c545-51c8-72f8-a89f-6d783a1f6577" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_01a0c545-51c8-718f-8888-6da8b57e3e8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7e51-91c8-9a65e1df9b92" xlink:to="loc_us-gaap_Goodwill_01a0c545-51c8-718f-8888-6da8b57e3e8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_01a0c545-51c8-70ca-b069-84bae9ccdb28" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7e51-91c8-9a65e1df9b92" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_01a0c545-51c8-70ca-b069-84bae9ccdb28" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/AcquisitionsScheduleofRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#AcquisitionsScheduleofRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/AcquisitionsScheduleofRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_01a0c545-51c8-7d53-be6b-b2205779c40f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_01a0c545-51c8-7d53-be6b-b2205779c40f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-75e2-b6d3-41ee5bbabd7e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_01a0c545-51c8-7d53-be6b-b2205779c40f" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-75e2-b6d3-41ee5bbabd7e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-75e2-b6d3-41ee5bbabd7e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-75e2-b6d3-41ee5bbabd7e" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-75e2-b6d3-41ee5bbabd7e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-7856-85fd-8c6c27df7105" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_01a0c545-51c8-75e2-b6d3-41ee5bbabd7e" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-7856-85fd-8c6c27df7105" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_CareTopCoPtyLtdMember_01a0c545-51c8-770d-9445-fc4e7bfcf8e9" xlink:href="cl-20260930.xsd#cl_CareTopCoPtyLtdMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_01a0c545-51c8-7856-85fd-8c6c27df7105" xlink:to="loc_cl_CareTopCoPtyLtdMember_01a0c545-51c8-770d-9445-fc4e7bfcf8e9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_01a0c545-51c8-7d42-9684-b89eb8a7f407" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_01a0c545-51c8-7d42-9684-b89eb8a7f407" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_01a0c545-51c8-79dc-a449-d77e556b7afd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_01a0c545-51c8-79dc-a449-d77e556b7afd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_01a0c545-51c8-7a46-ba97-065d46abdcc1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_01a0c545-51c8-7a46-ba97-065d46abdcc1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_01a0c545-51c8-71d2-96e2-8d4c4b0929ee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_01a0c545-51c8-71d2-96e2-8d4c4b0929ee" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_01a0c545-51c8-7162-8057-59996fa90b57" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_01a0c545-51c8-7162-8057-59996fa90b57" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_01a0c545-51c8-7955-b240-939366c2119b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_Goodwill_01a0c545-51c8-7955-b240-939366c2119b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0c545-51c8-79e2-9049-94cb67fecf6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_01a0c545-51c8-79e2-9049-94cb67fecf6e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a0c545-51c8-7e93-8795-09d2d935ed93" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_01a0c545-51c8-7049-9164-6ffe0cbbf95e" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredGoodwillAndLiabilitiesAssumedNet_01a0c545-51c8-7e93-8795-09d2d935ed93" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesNarrativeDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#RestructuringandRelatedImplementationChargesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7658-9dee-3bd334634f17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7658-9dee-3bd334634f17" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7727-9e40-eff879949500" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7727-9e40-eff879949500" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7727-9e40-eff879949500_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7727-9e40-eff879949500" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7727-9e40-eff879949500_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-729f-bf23-f53824543fea" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7727-9e40-eff879949500" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-729f-bf23-f53824543fea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7db5-8d25-3d7c08d17886" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-729f-bf23-f53824543fea" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7db5-8d25-3d7c08d17886" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_01a0c545-51c8-7951-8f98-fd090bba15b7" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:to="loc_srt_RangeAxis_01a0c545-51c8-7951-8f98-fd090bba15b7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a0c545-51c8-7951-8f98-fd090bba15b7_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_01a0c545-51c8-7951-8f98-fd090bba15b7" xlink:to="loc_srt_RangeMember_01a0c545-51c8-7951-8f98-fd090bba15b7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a0c545-51c8-7fef-8e4b-557fa387b44b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_01a0c545-51c8-7951-8f98-fd090bba15b7" xlink:to="loc_srt_RangeMember_01a0c545-51c8-7fef-8e4b-557fa387b44b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_01a0c545-51c8-7885-89f0-80b9c6129785" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a0c545-51c8-7fef-8e4b-557fa387b44b" xlink:to="loc_srt_MinimumMember_01a0c545-51c8-7885-89f0-80b9c6129785" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_01a0c545-51c8-7536-9561-9d321be36747" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a0c545-51c8-7fef-8e4b-557fa387b44b" xlink:to="loc_srt_MaximumMember_01a0c545-51c8-7536-9561-9d321be36747" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7a7a-bf62-3683cf8427d3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7a7a-bf62-3683cf8427d3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-7a7a-bf62-3683cf8427d3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7a7a-bf62-3683cf8427d3" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-7a7a-bf62-3683cf8427d3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-706c-ac57-f3d64071cbd2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7a7a-bf62-3683cf8427d3" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-706c-ac57-f3d64071cbd2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OneTimeTerminationBenefitsMember_01a0c545-51c8-7512-ab48-ffc81b0fb55e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OneTimeTerminationBenefitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-706c-ac57-f3d64071cbd2" xlink:to="loc_us-gaap_OneTimeTerminationBenefitsMember_01a0c545-51c8-7512-ab48-ffc81b0fb55e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_AssetRelatedCostsAndOthersMember_01a0c545-51c8-7c7f-8581-a0a54cd8f96e" xlink:href="cl-20260930.xsd#cl_AssetRelatedCostsAndOthersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-706c-ac57-f3d64071cbd2" xlink:to="loc_cl_AssetRelatedCostsAndOthersMember_01a0c545-51c8-7c7f-8581-a0a54cd8f96e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_01a0c545-51c8-78a3-8610-79a7e894ab17" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:to="loc_srt_StatementGeographicalAxis_01a0c545-51c8-78a3-8610-79a7e894ab17" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-78a3-8610-79a7e894ab17_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-78a3-8610-79a7e894ab17" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-78a3-8610-79a7e894ab17_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7853-a66c-0bb95642c7d1" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-78a3-8610-79a7e894ab17" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7853-a66c-0bb95642c7d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NorthAmericaMember_01a0c545-51c8-7bbc-9b79-60d23fd13975" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_NorthAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7853-a66c-0bb95642c7d1" xlink:to="loc_srt_NorthAmericaMember_01a0c545-51c8-7bbc-9b79-60d23fd13975" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LatinAmericaMember_01a0c545-51c8-7011-bcfa-95e03da4c999" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LatinAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7853-a66c-0bb95642c7d1" xlink:to="loc_srt_LatinAmericaMember_01a0c545-51c8-7011-bcfa-95e03da4c999" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EMEAMember_01a0c545-51c8-7bb6-90a4-4eca1dc71d9a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EMEAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7853-a66c-0bb95642c7d1" xlink:to="loc_us-gaap_EMEAMember_01a0c545-51c8-7bb6-90a4-4eca1dc71d9a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaPacificMember_01a0c545-51c8-7443-b84a-67b88840f34a" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_AsiaPacificMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7853-a66c-0bb95642c7d1" xlink:to="loc_srt_AsiaPacificMember_01a0c545-51c8-7443-b84a-67b88840f34a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7b8b-8301-684618aea734" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7b8b-8301-684618aea734" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7b8b-8301-684618aea734_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7b8b-8301-684618aea734" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7b8b-8301-684618aea734_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7316-8a0c-0aa703ae9501" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7b8b-8301-684618aea734" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7316-8a0c-0aa703ae9501" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_HillsPetNutritionMember_01a0c545-51c8-7d6b-94e3-8a8b5f35bd25" xlink:href="cl-20260930.xsd#cl_HillsPetNutritionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-7316-8a0c-0aa703ae9501" xlink:to="loc_cl_HillsPetNutritionMember_01a0c545-51c8-7d6b-94e3-8a8b5f35bd25" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateMember_01a0c545-51c8-74ec-9644-d3b2de6c5f05" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-7316-8a0c-0aa703ae9501" xlink:to="loc_us-gaap_CorporateMember_01a0c545-51c8-74ec-9644-d3b2de6c5f05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7421-82e1-9f7b459e7da9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-728d-b982-8aaf77ba1fe3" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7421-82e1-9f7b459e7da9" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7421-82e1-9f7b459e7da9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7421-82e1-9f7b459e7da9" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7421-82e1-9f7b459e7da9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7e9d-b877-43883a594edc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7421-82e1-9f7b459e7da9" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7e9d-b877-43883a594edc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_01a0c545-51c8-74c5-a500-8f1b3bba61e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7e9d-b877-43883a594edc" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_01a0c545-51c8-74c5-a500-8f1b3bba61e6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringProgramPeriodInForce_01a0c545-51c8-7752-a8af-6bb26f2afa1b" xlink:href="cl-20260930.xsd#cl_RestructuringProgramPeriodInForce"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7658-9dee-3bd334634f17" xlink:to="loc_cl_RestructuringProgramPeriodInForce_01a0c545-51c8-7752-a8af-6bb26f2afa1b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_01a0c545-51c8-754c-ba23-8a4af0bda136" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostExpectedCost1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7658-9dee-3bd334634f17" xlink:to="loc_us-gaap_RestructuringAndRelatedCostExpectedCost1_01a0c545-51c8-754c-ba23-8a4af0bda136" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringAndRelatedCostExpectedCostPercent_01a0c545-51c8-7bf6-a840-22ddd0a502db" xlink:href="cl-20260930.xsd#cl_RestructuringAndRelatedCostExpectedCostPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7658-9dee-3bd334634f17" xlink:to="loc_cl_RestructuringAndRelatedCostExpectedCostPercent_01a0c545-51c8-7bf6-a840-22ddd0a502db" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringAndRelatedCostExpectedCostCashPercent_01a0c545-51c8-78a3-83e6-07f73cb58bad" xlink:href="cl-20260930.xsd#cl_RestructuringAndRelatedCostExpectedCostCashPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7658-9dee-3bd334634f17" xlink:to="loc_cl_RestructuringAndRelatedCostExpectedCostCashPercent_01a0c545-51c8-78a3-83e6-07f73cb58bad" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_01a0c545-51c8-7899-a008-51bc0e9bcf19" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7658-9dee-3bd334634f17" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_01a0c545-51c8-7899-a008-51bc0e9bcf19" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringandRelatedCostsDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#RestructuringandRelatedImplementationChargesScheduleofRestructuringandRelatedCostsDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringandRelatedCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-78aa-8bfb-9d987250b6bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-78aa-8bfb-9d987250b6bf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-78aa-8bfb-9d987250b6bf" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-76da-a8e2-026d1a272894_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-76da-a8e2-026d1a272894_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7395-a878-c42add085516" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7395-a878-c42add085516" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7034-bdb4-c558171e0668" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7395-a878-c42add085516" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7034-bdb4-c558171e0668" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_01a0c545-51c8-7bbf-90ad-8bf02e797438" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-78aa-8bfb-9d987250b6bf" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_01a0c545-51c8-7bbf-90ad-8bf02e797438" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostIncurredCost_01a0c545-51c8-7b82-95da-e7ce3bb3a4f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostIncurredCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:to="loc_us-gaap_RestructuringAndRelatedCostIncurredCost_01a0c545-51c8-7b82-95da-e7ce3bb3a4f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringAndRelatedCostIncurredCostAfterTax_01a0c545-51c8-76d1-8c4a-9d99a0b7cd58" xlink:href="cl-20260930.xsd#cl_RestructuringAndRelatedCostIncurredCostAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:to="loc_cl_RestructuringAndRelatedCostIncurredCostAfterTax_01a0c545-51c8-76d1-8c4a-9d99a0b7cd58" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringandRelatedCostsDetails_1" xlink:type="simple" xlink:href="cl-20260930.xsd#RestructuringandRelatedImplementationChargesScheduleofRestructuringandRelatedCostsDetails_1"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringandRelatedCostsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-78aa-8bfb-9d987250b6bf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-78aa-8bfb-9d987250b6bf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-78aa-8bfb-9d987250b6bf" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-76da-a8e2-026d1a272894_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-76da-a8e2-026d1a272894_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7395-a878-c42add085516" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-76da-a8e2-026d1a272894" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7395-a878-c42add085516" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7034-bdb4-c558171e0668" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7395-a878-c42add085516" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7034-bdb4-c558171e0668" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostIncurredCost_01a0c545-51c8-7b82-95da-e7ce3bb3a4f1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostIncurredCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:to="loc_us-gaap_RestructuringAndRelatedCostIncurredCost_01a0c545-51c8-7b82-95da-e7ce3bb3a4f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringAndRelatedCostIncurredCostAfterTax_01a0c545-51c8-76d1-8c4a-9d99a0b7cd58" xlink:href="cl-20260930.xsd#cl_RestructuringAndRelatedCostIncurredCostAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7cfe-93ac-fd0dbbc7e7bc" xlink:to="loc_cl_RestructuringAndRelatedCostIncurredCostAfterTax_01a0c545-51c8-76d1-8c4a-9d99a0b7cd58" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringChargesIncurredbySegmentDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#RestructuringandRelatedImplementationChargesScheduleofRestructuringChargesIncurredbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringChargesIncurredbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7d28-9936-fb8d1584bb6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-796d-a630-1b160a4d1b9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7d28-9936-fb8d1584bb6e" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-796d-a630-1b160a4d1b9c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7f48-beb5-3a525f28c8d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-796d-a630-1b160a4d1b9c" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7f48-beb5-3a525f28c8d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7f48-beb5-3a525f28c8d5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7f48-beb5-3a525f28c8d5" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7f48-beb5-3a525f28c8d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7faa-98f1-9c2194c41b69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7f48-beb5-3a525f28c8d5" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7faa-98f1-9c2194c41b69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-787a-a57c-c19a936bf809" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7faa-98f1-9c2194c41b69" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-787a-a57c-c19a936bf809" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7252-8405-06830122897d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-796d-a630-1b160a4d1b9c" xlink:to="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7252-8405-06830122897d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7252-8405-06830122897d_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7252-8405-06830122897d" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7252-8405-06830122897d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-755c-9460-45354735504c" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7252-8405-06830122897d" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-755c-9460-45354735504c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NorthAmericaMember_01a0c545-51c8-7f6c-a58c-63f26e6fca3e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_NorthAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-755c-9460-45354735504c" xlink:to="loc_srt_NorthAmericaMember_01a0c545-51c8-7f6c-a58c-63f26e6fca3e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LatinAmericaMember_01a0c545-51c8-7187-a406-83fdd4e38c66" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LatinAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-755c-9460-45354735504c" xlink:to="loc_srt_LatinAmericaMember_01a0c545-51c8-7187-a406-83fdd4e38c66" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EMEAMember_01a0c545-51c8-79bd-842f-b5fa24b9e902" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EMEAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-755c-9460-45354735504c" xlink:to="loc_us-gaap_EMEAMember_01a0c545-51c8-79bd-842f-b5fa24b9e902" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaPacificMember_01a0c545-51c8-7806-ad48-ce7dc868fbcf" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_AsiaPacificMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-755c-9460-45354735504c" xlink:to="loc_srt_AsiaPacificMember_01a0c545-51c8-7806-ad48-ce7dc868fbcf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-790d-8b94-ace07dc8174f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-796d-a630-1b160a4d1b9c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-790d-8b94-ace07dc8174f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-790d-8b94-ace07dc8174f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-790d-8b94-ace07dc8174f" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-790d-8b94-ace07dc8174f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7c2c-9177-fd22ded5d366" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-790d-8b94-ace07dc8174f" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7c2c-9177-fd22ded5d366" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_HillsPetNutritionMember_01a0c545-51c8-709a-bd51-f18d1147ce7b" xlink:href="cl-20260930.xsd#cl_HillsPetNutritionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-7c2c-9177-fd22ded5d366" xlink:to="loc_cl_HillsPetNutritionMember_01a0c545-51c8-709a-bd51-f18d1147ce7b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateMember_01a0c545-51c8-7140-9a56-5e7772c210a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-7c2c-9177-fd22ded5d366" xlink:to="loc_us-gaap_CorporateMember_01a0c545-51c8-7140-9a56-5e7772c210a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringAndRelatedCostIncurredCostPercent_01a0c545-51c8-7c60-bdfe-40dd3fc7b843" xlink:href="cl-20260930.xsd#cl_RestructuringAndRelatedCostIncurredCostPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7d28-9936-fb8d1584bb6e" xlink:to="loc_cl_RestructuringAndRelatedCostIncurredCostPercent_01a0c545-51c8-7c60-bdfe-40dd3fc7b843" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringAndRelatedCostAccumulatedChargesPercent_01a0c545-51c8-7ded-ae3b-53700ed1caab" xlink:href="cl-20260930.xsd#cl_RestructuringAndRelatedCostAccumulatedChargesPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7d28-9936-fb8d1584bb6e" xlink:to="loc_cl_RestructuringAndRelatedCostAccumulatedChargesPercent_01a0c545-51c8-7ded-ae3b-53700ed1caab" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringChargesCumulativetoDateDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#RestructuringandRelatedImplementationChargesScheduleofRestructuringChargesCumulativetoDateDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringChargesCumulativetoDateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7939-9167-8289fe8c2eb5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-71a7-8960-b7178526599e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7939-9167-8289fe8c2eb5" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-71a7-8960-b7178526599e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-718b-8c45-27ea487b793a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-71a7-8960-b7178526599e" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-718b-8c45-27ea487b793a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-718b-8c45-27ea487b793a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-718b-8c45-27ea487b793a" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-718b-8c45-27ea487b793a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-70e7-a13f-21f7ab790ef2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-718b-8c45-27ea487b793a" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-70e7-a13f-21f7ab790ef2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7736-b360-84aa9609ac02" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-70e7-a13f-21f7ab790ef2" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-7736-b360-84aa9609ac02" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-707a-b568-f9ca8ac0cceb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-71a7-8960-b7178526599e" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-707a-b568-f9ca8ac0cceb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-707a-b568-f9ca8ac0cceb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-707a-b568-f9ca8ac0cceb" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-707a-b568-f9ca8ac0cceb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-74b5-ba9d-4e6d47cad4de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-707a-b568-f9ca8ac0cceb" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-74b5-ba9d-4e6d47cad4de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OneTimeTerminationBenefitsMember_01a0c545-51c8-72cc-bf18-1c98b04b0f6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OneTimeTerminationBenefitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-74b5-ba9d-4e6d47cad4de" xlink:to="loc_us-gaap_OneTimeTerminationBenefitsMember_01a0c545-51c8-72cc-bf18-1c98b04b0f6e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_AssetRelatedCostsAndOthersMember_01a0c545-51c8-7bff-9f2f-014585dac006" xlink:href="cl-20260930.xsd#cl_AssetRelatedCostsAndOthersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-74b5-ba9d-4e6d47cad4de" xlink:to="loc_cl_AssetRelatedCostsAndOthersMember_01a0c545-51c8-7bff-9f2f-014585dac006" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_01a0c545-51c8-7dde-a856-ec543d039c51" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringAndRelatedCostCostIncurredToDate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7939-9167-8289fe8c2eb5" xlink:to="loc_us-gaap_RestructuringAndRelatedCostCostIncurredToDate1_01a0c545-51c8-7dde-a856-ec543d039c51" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RestructuringAndRelatedCostIncurredCostToDateAfterTax_01a0c545-51c8-7d07-8618-60443f88e2f9" xlink:href="cl-20260930.xsd#cl_RestructuringAndRelatedCostIncurredCostToDateAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-7939-9167-8289fe8c2eb5" xlink:to="loc_cl_RestructuringAndRelatedCostIncurredCostToDateAfterTax_01a0c545-51c8-7d07-8618-60443f88e2f9" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringActivityandRelatedAccrualsDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#RestructuringandRelatedImplementationChargesScheduleofRestructuringActivityandRelatedAccrualsDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RestructuringandRelatedImplementationChargesScheduleofRestructuringActivityandRelatedAccrualsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-712d-8519-1b4ec84fa8f5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-7305-95fc-f791933ddafd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-712d-8519-1b4ec84fa8f5" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-7305-95fc-f791933ddafd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7b5d-abb2-a8efb726866f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-7305-95fc-f791933ddafd" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7b5d-abb2-a8efb726866f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7b5d-abb2-a8efb726866f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7b5d-abb2-a8efb726866f" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7b5d-abb2-a8efb726866f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7bfc-803f-59a7e33aec52" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-7b5d-abb2-a8efb726866f" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7bfc-803f-59a7e33aec52" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-72b3-b248-c052c3f144ba" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7bfc-803f-59a7e33aec52" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-72b3-b248-c052c3f144ba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7014-81ba-4a3c8ea9b6e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_01a0c545-51c8-7305-95fc-f791933ddafd" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7014-81ba-4a3c8ea9b6e0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-7014-81ba-4a3c8ea9b6e0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7014-81ba-4a3c8ea9b6e0" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-7014-81ba-4a3c8ea9b6e0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-738d-890b-1e3d58ebf927" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_01a0c545-51c8-7014-81ba-4a3c8ea9b6e0" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-738d-890b-1e3d58ebf927" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OneTimeTerminationBenefitsMember_01a0c545-51c8-76fe-94b6-46b57b83f694" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OneTimeTerminationBenefitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-738d-890b-1e3d58ebf927" xlink:to="loc_us-gaap_OneTimeTerminationBenefitsMember_01a0c545-51c8-76fe-94b6-46b57b83f694" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_01a0c545-51c8-755b-9f3e-ad18681514a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_01a0c545-51c8-738d-890b-1e3d58ebf927" xlink:to="loc_us-gaap_OtherRestructuringMember_01a0c545-51c8-755b-9f3e-ad18681514a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_01a0c545-51c8-7fda-960c-cdbbed501a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_01a0c545-51c8-712d-8519-1b4ec84fa8f5" xlink:to="loc_us-gaap_RestructuringReserveRollForward_01a0c545-51c8-7fda-960c-cdbbed501a0b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_01a0c545-51c8-7a5c-beaf-323421b50a4b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_01a0c545-51c8-7fda-960c-cdbbed501a0b" xlink:to="loc_us-gaap_RestructuringReserve_01a0c545-51c8-7a5c-beaf-323421b50a4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_01a0c545-51c8-7d91-9e21-bcc888400a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_01a0c545-51c8-7fda-960c-cdbbed501a0b" xlink:to="loc_us-gaap_RestructuringCharges_01a0c545-51c8-7d91-9e21-bcc888400a9d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_01a0c545-51c8-7a0a-b752-43a103d87847" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_01a0c545-51c8-7fda-960c-cdbbed501a0b" xlink:to="loc_us-gaap_PaymentsForRestructuring_01a0c545-51c8-7a0a-b752-43a103d87847" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveSettledWithoutCash2_01a0c545-51c8-7397-aebc-921cb3589f9d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveSettledWithoutCash2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_01a0c545-51c8-7fda-960c-cdbbed501a0b" xlink:to="loc_us-gaap_RestructuringReserveSettledWithoutCash2_01a0c545-51c8-7397-aebc-921cb3589f9d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveTranslationAdjustment_01a0c545-51c8-7aa8-a840-4b4637f70113" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserveTranslationAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_01a0c545-51c8-7fda-960c-cdbbed501a0b" xlink:to="loc_us-gaap_RestructuringReserveTranslationAdjustment_01a0c545-51c8-7aa8-a840-4b4637f70113" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_01a0c545-51c8-79ed-9aba-c63e7a991f45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringReserve"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/OtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#OtherComprehensiveIncomeLossDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/OtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_01a0c545-51c8-7e36-a974-905e9b8893ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_01a0c545-51c8-7f2b-87e9-b861d6efe1ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_01a0c545-51c8-7e36-a974-905e9b8893ac" xlink:to="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_01a0c545-51c8-7f2b-87e9-b861d6efe1ad" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-7a02-b36b-577d7448ed9c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ReclassificationOutOfAccumulatedOtherComprehensiveIncomeTable_01a0c545-51c8-7f2b-87e9-b861d6efe1ad" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-7a02-b36b-577d7448ed9c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7a02-b36b-577d7448ed9c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-7a02-b36b-577d7448ed9c" xlink:to="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7a02-b36b-577d7448ed9c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7329-b4f4-fcad83d1042b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_01a0c545-51c8-7a02-b36b-577d7448ed9c" xlink:to="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7329-b4f4-fcad83d1042b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a0c545-51c8-7394-b2a4-dcdb5a3056eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_01a0c545-51c8-7329-b4f4-fcad83d1042b" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a0c545-51c8-7394-b2a4-dcdb5a3056eb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_01a0c545-51c8-7e18-a17c-790d21adbd83" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a0c545-51c8-7394-b2a4-dcdb5a3056eb" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_01a0c545-51c8-7e18-a17c-790d21adbd83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_01a0c545-51c8-7438-b529-1ef337ec11e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a0c545-51c8-7394-b2a4-dcdb5a3056eb" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember_01a0c545-51c8-7438-b529-1ef337ec11e0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_01a0c545-51c8-73c0-ab30-090151c149e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_01a0c545-51c8-7394-b2a4-dcdb5a3056eb" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_01a0c545-51c8-73c0-ab30-090151c149e1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_01a0c545-51c8-76f8-825f-3886abd35519" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_01a0c545-51c8-7e36-a974-905e9b8893ac" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_01a0c545-51c8-76f8-825f-3886abd35519" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_01a0c545-51c8-745c-b80d-04210361a8ae" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_01a0c545-51c8-7e36-a974-905e9b8893ac" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsBeforeTax_01a0c545-51c8-745c-b80d-04210361a8ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_01a0c545-51c8-70a9-bd98-121e31e0f046" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_01a0c545-51c8-7e36-a974-905e9b8893ac" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_01a0c545-51c8-70a9-bd98-121e31e0f046" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeTax_01a0c545-51c8-736b-80f0-b5428c72a597" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_01a0c545-51c8-7a25-ad45-d58b011bb37e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_01a0c545-51c8-7e36-a974-905e9b8893ac" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_01a0c545-51c8-7a25-ad45-d58b011bb37e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_01a0c545-51c8-774d-98a9-d12edc8305e3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationAdjustmentOutOfAccumulatedOtherComprehensiveIncomeLineItems_01a0c545-51c8-7e36-a974-905e9b8893ac" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_01a0c545-51c8-774d-98a9-d12edc8305e3" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RetirementPlansandOtherRetireeBenefitsScheduleofComponentsofNetPeriodicBenefitCostDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#RetirementPlansandOtherRetireeBenefitsScheduleofComponentsofNetPeriodicBenefitCostDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RetirementPlansandOtherRetireeBenefitsScheduleofComponentsofNetPeriodicBenefitCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_01a0c545-51c8-7e5f-aae8-badf9451c0fb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0c545-51c8-7cc4-84fd-c009ee358879" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_01a0c545-51c8-7e5f-aae8-badf9451c0fb" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0c545-51c8-7cc4-84fd-c009ee358879" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7eeb-b26a-99ad774919bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0c545-51c8-7cc4-84fd-c009ee358879" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7eeb-b26a-99ad774919bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7eeb-b26a-99ad774919bc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7eeb-b26a-99ad774919bc" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7eeb-b26a-99ad774919bc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7225-8eac-8dededdb781c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_01a0c545-51c8-7eeb-b26a-99ad774919bc" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7225-8eac-8dededdb781c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_01a0c545-51c8-7c65-9461-e2ad462cf348" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7225-8eac-8dededdb781c" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_01a0c545-51c8-7c65-9461-e2ad462cf348" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_01a0c545-51c8-7480-b768-acf304588f2d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_01a0c545-51c8-7225-8eac-8dededdb781c" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_01a0c545-51c8-7480-b768-acf304588f2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationAxis_01a0c545-51c8-7925-8e44-c4d163e91b43" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanSponsorLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0c545-51c8-7cc4-84fd-c009ee358879" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationAxis_01a0c545-51c8-7925-8e44-c4d163e91b43" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationDomain_01a0c545-51c8-7925-8e44-c4d163e91b43_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanSponsorLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationAxis_01a0c545-51c8-7925-8e44-c4d163e91b43" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationDomain_01a0c545-51c8-7925-8e44-c4d163e91b43_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationDomain_01a0c545-51c8-7926-8775-c992e10d5872" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanSponsorLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationAxis_01a0c545-51c8-7925-8e44-c4d163e91b43" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationDomain_01a0c545-51c8-7926-8775-c992e10d5872" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticPlanMember_01a0c545-51c8-7440-978c-694e68c0e1ca" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DomesticPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationDomain_01a0c545-51c8-7926-8775-c992e10d5872" xlink:to="loc_us-gaap_DomesticPlanMember_01a0c545-51c8-7440-978c-694e68c0e1ca" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_01a0c545-51c8-7586-83e8-4d63e3fa13df" xlink:href="https://xbrl.sec.gov/country/2026/country-2026.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DomesticPlanMember_01a0c545-51c8-7440-978c-694e68c0e1ca" xlink:to="loc_country_US_01a0c545-51c8-7586-83e8-4d63e3fa13df" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignPlanMember_01a0c545-51c8-74b2-80ad-730c20d879e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationDomain_01a0c545-51c8-7926-8775-c992e10d5872" xlink:to="loc_us-gaap_ForeignPlanMember_01a0c545-51c8-74b2-80ad-730c20d879e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_InternationalMember_01a0c545-51c8-75ab-adf7-dd88dd997ec1" xlink:href="cl-20260930.xsd#cl_InternationalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ForeignPlanMember_01a0c545-51c8-74b2-80ad-730c20d879e0" xlink:to="loc_cl_InternationalMember_01a0c545-51c8-75ab-adf7-dd88dd997ec1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_01a0c545-51c8-7e5f-aae8-badf9451c0fb" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanServiceCost_01a0c545-51c8-7790-8ace-2bf83d46acc0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanServiceCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_DefinedBenefitPlanServiceCost_01a0c545-51c8-7790-8ace-2bf83d46acc0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_01a0c545-51c8-729e-b46c-c5d5061f091d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_01a0c545-51c8-729e-b46c-c5d5061f091d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_01a0c545-51c8-72d3-8730-88383281b01d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_01a0c545-51c8-72d3-8730-88383281b01d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_01a0c545-51c8-763d-9d73-bc46222380fc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_01a0c545-51c8-763d-9d73-bc46222380fc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_01a0c545-51c8-75aa-8a10-951fa14c024a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_01a0c545-51c8-75aa-8a10-951fa14c024a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanOtherCosts_01a0c545-51c8-79e9-a521-f538c0f98435" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanOtherCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_DefinedBenefitPlanOtherCosts_01a0c545-51c8-79e9-a521-f538c0f98435" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-7772-b47a-753b1e427d89" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-7772-b47a-753b1e427d89" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionAndOtherPostretirementBenefitExpense_01a0c545-51c8-7a49-88b4-9b2166c03685" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PensionAndOtherPostretirementBenefitExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_01a0c545-51c8-7751-b954-5b771a2d63a7" xlink:to="loc_us-gaap_PensionAndOtherPostretirementBenefitExpense_01a0c545-51c8-7a49-88b4-9b2166c03685" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/RetirementPlansandOtherRetireeBenefitsNarrativeDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#RetirementPlansandOtherRetireeBenefitsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/RetirementPlansandOtherRetireeBenefitsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_01a0e7e9-66b4-73a5-93bf-8f35b7f63e21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0e7e9-66b4-7c1c-89f6-48576dc66b0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_01a0e7e9-66b4-73a5-93bf-8f35b7f63e21" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0e7e9-66b4-7c1c-89f6-48576dc66b0b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_01a13a18-5476-74af-b173-7f5525a9a555" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0e7e9-66b4-7c1c-89f6-48576dc66b0b" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_01a13a18-5476-74af-b173-7f5525a9a555" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_01a13a18-5476-74af-b173-7f5525a9a555_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_01a13a18-5476-74af-b173-7f5525a9a555" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_01a13a18-5476-74af-b173-7f5525a9a555_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_01a13a18-5476-78b8-9c6b-59b87d79c3fd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_01a13a18-5476-74af-b173-7f5525a9a555" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_01a13a18-5476-78b8-9c6b-59b87d79c3fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_01a13a18-5476-787e-b100-1c208ac415d5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_01a13a18-5476-78b8-9c6b-59b87d79c3fd" xlink:to="loc_us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember_01a13a18-5476-787e-b100-1c208ac415d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a13a1b-6aa6-747e-beb4-ba0cd71a1acc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_01a0e7e9-66b4-7c1c-89f6-48576dc66b0b" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a13a1b-6aa6-747e-beb4-ba0cd71a1acc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a13a1b-6aa6-747e-beb4-ba0cd71a1acc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a13a1b-6aa6-747e-beb4-ba0cd71a1acc" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a13a1b-6aa6-747e-beb4-ba0cd71a1acc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a13a1b-6aa6-7b0f-bdd3-b5e39e1775e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a13a1b-6aa6-747e-beb4-ba0cd71a1acc" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a13a1b-6aa6-7b0f-bdd3-b5e39e1775e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a13a1b-6aa6-7c65-89e5-b8a000dcdd7b" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a13a1b-6aa6-7b0f-bdd3-b5e39e1775e6" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a13a1b-6aa6-7c65-89e5-b8a000dcdd7b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanOtherCosts_01a0e7ee-f906-7565-bdd3-fa10f13074c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DefinedBenefitPlanOtherCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_01a0e7e9-66b4-73a5-93bf-8f35b7f63e21" xlink:to="loc_us-gaap_DefinedBenefitPlanOtherCosts_01a0e7ee-f906-7565-bdd3-fa10f13074c4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/ContingenciesDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#ContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/ContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_01a0c545-51c8-7f7b-ae62-8a6f9eb35e5a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_us-gaap_LossContingenciesTable_01a0c545-51c8-7f7b-ae62-8a6f9eb35e5a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_01a0c545-51c8-7ba4-8770-deebb9230b70" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_01a0c545-51c8-7f7b-ae62-8a6f9eb35e5a" xlink:to="loc_srt_LitigationCaseAxis_01a0c545-51c8-7ba4-8770-deebb9230b70" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-7ba4-8770-deebb9230b70_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_01a0c545-51c8-7ba4-8770-deebb9230b70" xlink:to="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-7ba4-8770-deebb9230b70_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-785c-829b-f9c7b80d4f01" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_01a0c545-51c8-7ba4-8770-deebb9230b70" xlink:to="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-785c-829b-f9c7b80d4f01" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_BrazilianMattersMember_01a0c545-51c8-701c-8a0d-baabef2b4ac4" xlink:href="cl-20260930.xsd#cl_BrazilianMattersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-785c-829b-f9c7b80d4f01" xlink:to="loc_cl_BrazilianMattersMember_01a0c545-51c8-701c-8a0d-baabef2b4ac4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_BrazilianMatterAppealedByBrazilianFederalGovernmentMember_01a0c545-51c8-772d-b10e-604f3e6c9110" xlink:href="cl-20260930.xsd#cl_BrazilianMatterAppealedByBrazilianFederalGovernmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-785c-829b-f9c7b80d4f01" xlink:to="loc_cl_BrazilianMatterAppealedByBrazilianFederalGovernmentMember_01a0c545-51c8-772d-b10e-604f3e6c9110" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_BrazilianMatterAppealedByTheCompanyMember_01a0c545-51c8-7d6c-ad92-7f0e65a5529b" xlink:href="cl-20260930.xsd#cl_BrazilianMatterAppealedByTheCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-785c-829b-f9c7b80d4f01" xlink:to="loc_cl_BrazilianMatterAppealedByTheCompanyMember_01a0c545-51c8-7d6c-ad92-7f0e65a5529b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_TalcumPowderMattersMember_01a0c545-51c8-7b19-909c-859de5a3879d" xlink:href="cl-20260930.xsd#cl_TalcumPowderMattersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_01a0c545-51c8-785c-829b-f9c7b80d4f01" xlink:to="loc_cl_TalcumPowderMattersMember_01a0c545-51c8-7b19-909c-859de5a3879d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusAxis_01a0c545-51c8-7e9e-a2fe-77d63898af25" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_01a0c545-51c8-7f7b-ae62-8a6f9eb35e5a" xlink:to="loc_us-gaap_LitigationStatusAxis_01a0c545-51c8-7e9e-a2fe-77d63898af25" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_01a0c545-51c8-7e9e-a2fe-77d63898af25_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationStatusAxis_01a0c545-51c8-7e9e-a2fe-77d63898af25" xlink:to="loc_us-gaap_LitigationStatusDomain_01a0c545-51c8-7e9e-a2fe-77d63898af25_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationStatusDomain_01a0c545-51c8-7630-9012-a37988807218" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationStatusDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationStatusAxis_01a0c545-51c8-7e9e-a2fe-77d63898af25" xlink:to="loc_us-gaap_LitigationStatusDomain_01a0c545-51c8-7630-9012-a37988807218" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_JudicialRulingMember_01a0c545-51c8-7efe-a738-37abd63c1b1e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_JudicialRulingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationStatusDomain_01a0c545-51c8-7630-9012-a37988807218" xlink:to="loc_us-gaap_JudicialRulingMember_01a0c545-51c8-7efe-a738-37abd63c1b1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SettledLitigationMember_01a0c545-51c8-73aa-adda-bdcf48d67836" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SettledLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationStatusDomain_01a0c545-51c8-7630-9012-a37988807218" xlink:to="loc_us-gaap_SettledLitigationMember_01a0c545-51c8-73aa-adda-bdcf48d67836" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_01a15a52-0344-782a-92a6-7cbd7e7e8bf4" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_01a0c545-51c8-7f7b-ae62-8a6f9eb35e5a" xlink:to="loc_srt_RangeAxis_01a15a52-0344-782a-92a6-7cbd7e7e8bf4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a15a52-0344-782a-92a6-7cbd7e7e8bf4_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_01a15a52-0344-782a-92a6-7cbd7e7e8bf4" xlink:to="loc_srt_RangeMember_01a15a52-0344-782a-92a6-7cbd7e7e8bf4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_01a15a52-0344-76f0-b194-10765e653764" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_01a15a52-0344-782a-92a6-7cbd7e7e8bf4" xlink:to="loc_srt_RangeMember_01a15a52-0344-76f0-b194-10765e653764" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_01a15a52-fa34-772b-8874-84a12c838140" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a15a52-0344-76f0-b194-10765e653764" xlink:to="loc_srt_MinimumMember_01a15a52-fa34-772b-8874-84a12c838140" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_01a15a52-0344-7606-8635-5e64bd99e646" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_01a15a52-0344-76f0-b194-10765e653764" xlink:to="loc_srt_MaximumMember_01a15a52-0344-7606-8635-5e64bd99e646" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_MinimumNumberOfCountriesAndTerritoriesServingConsumers_01a0c545-51c8-73aa-b3dd-e7cd6ce15887" xlink:href="cl-20260930.xsd#cl_MinimumNumberOfCountriesAndTerritoriesServingConsumers"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_cl_MinimumNumberOfCountriesAndTerritoriesServingConsumers_01a0c545-51c8-73aa-b3dd-e7cd6ce15887" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_01a0c545-51c8-732c-89d8-8c06988396f3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyEstimateOfPossibleLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_us-gaap_LossContingencyEstimateOfPossibleLoss_01a0c545-51c8-732c-89d8-8c06988396f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_TaxAssessmentsWithInterest_01a0c545-51c8-70ce-b3f1-42793868dfb9" xlink:href="cl-20260930.xsd#cl_TaxAssessmentsWithInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_cl_TaxAssessmentsWithInterest_01a0c545-51c8-70ce-b3f1-42793868dfb9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNewClaimsFiledNumber_01a0c545-51c8-70a5-aed8-747b454ef9be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyNewClaimsFiledNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_us-gaap_LossContingencyNewClaimsFiledNumber_01a0c545-51c8-70a5-aed8-747b454ef9be" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_LossContingencyNumberOfCasesPendingInLowerFederalCourt_01a0c545-51c8-744f-a6f7-d5d394791348" xlink:href="cl-20260930.xsd#cl_LossContingencyNumberOfCasesPendingInLowerFederalCourt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_cl_LossContingencyNumberOfCasesPendingInLowerFederalCourt_01a0c545-51c8-744f-a6f7-d5d394791348" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_LossContingencyNumberOfCasesOnAppeal_01a0c545-51c8-71ab-9edd-cc2a67084940" xlink:href="cl-20260930.xsd#cl_LossContingencyNumberOfCasesOnAppeal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_cl_LossContingencyNumberOfCasesOnAppeal_01a0c545-51c8-71ab-9edd-cc2a67084940" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_TaxAssessmentsWithInterestAndPenalties_01a0c545-51c8-7366-a59c-56299b8ada9e" xlink:href="cl-20260930.xsd#cl_TaxAssessmentsWithInterestAndPenalties"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_cl_TaxAssessmentsWithInterestAndPenalties_01a0c545-51c8-7366-a59c-56299b8ada9e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyPendingClaimsNumber_01a0c545-51c8-7816-9f8e-d6f69787939d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyPendingClaimsNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_us-gaap_LossContingencyPendingClaimsNumber_01a0c545-51c8-7816-9f8e-d6f69787939d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyClaimsSettledAndDismissedNumber_01a0c545-51c8-782f-848b-dbeb8e9f182a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LossContingencyClaimsSettledAndDismissedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_us-gaap_LossContingencyClaimsSettledAndDismissedNumber_01a0c545-51c8-782f-848b-dbeb8e9f182a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-7042-99ae-094050f2ff3d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_01a0c545-51c8-7042-ac78-4f31b858b805" xlink:to="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-7042-99ae-094050f2ff3d" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/SegmentInformationNarrativeDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#SegmentInformationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/SegmentInformationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7775-96e9-5b7dbd72bcdb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7775-96e9-5b7dbd72bcdb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7286-9397-07af59ba2f79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7286-9397-07af59ba2f79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_AsiaPacificSegmentMember_01a0c545-51c8-76e9-afcc-9ced32bb8f36" xlink:href="cl-20260930.xsd#cl_AsiaPacificSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-7286-9397-07af59ba2f79" xlink:to="loc_cl_AsiaPacificSegmentMember_01a0c545-51c8-76e9-afcc-9ced32bb8f36" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7101-8992-99fee05f0923_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7101-8992-99fee05f0923_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7fcd-bbea-f49828760163" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7fcd-bbea-f49828760163" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RussiaAndBelarusMember_01a0c545-51c8-7b9c-bc4a-16413913c1a4" xlink:href="cl-20260930.xsd#cl_RussiaAndBelarusMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7fcd-bbea-f49828760163" xlink:to="loc_cl_RussiaAndBelarusMember_01a0c545-51c8-7b9c-bc4a-16413913c1a4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7b42-a22b-76c222665cd7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7b42-a22b-76c222665cd7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7575-8ab5-3d8e70cdd426" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7575-8ab5-3d8e70cdd426" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_01a0c545-51c8-7ef9-8d1c-c1e098fad88c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7575-8ab5-3d8e70cdd426" xlink:to="loc_us-gaap_SalesRevenueNetMember_01a0c545-51c8-7ef9-8d1c-c1e098fad88c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7908-80e7-f78efe12155a_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:to="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7908-80e7-f78efe12155a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-74ff-86f4-8a165b8b4a4d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:to="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-74ff-86f4-8a165b8b4a4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_01a0c545-51c8-77db-bbeb-4813ddc0f61f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-74ff-86f4-8a165b8b4a4d" xlink:to="loc_us-gaap_CorporateNonSegmentMember_01a0c545-51c8-77db-bbeb-4813ddc0f61f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-74b5-9ef8-7891c8fb0924_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-74b5-9ef8-7891c8fb0924_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7fcc-9410-a34abd4eeb9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7fcc-9410-a34abd4eeb9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-769e-be16-070a62645cb1" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7fcc-9410-a34abd4eeb9f" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-769e-be16-070a62645cb1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_01a13a1f-bf37-78cd-b704-17d9aed5d6e1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementOfIncomeLocationBalanceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_us-gaap_StatementOfIncomeLocationBalanceAxis_01a13a1f-bf37-78cd-b704-17d9aed5d6e1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_01a0c545-51c8-771c-9f69-e9d4d0c189b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_NumberOfOperatingSegments_01a0c545-51c8-771c-9f69-e9d4d0c189b0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_01a0c545-51c8-72d3-954d-2dec7a3277e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_NumberOfReportableSegments_01a0c545-51c8-72d3-954d-2dec7a3277e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_NumberOfGeographicallyReportableOperatingSegments_01a0c545-51c8-7ad6-b902-d25cfd626eb0" xlink:href="cl-20260930.xsd#cl_NumberOfGeographicallyReportableOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_cl_NumberOfGeographicallyReportableOperatingSegments_01a0c545-51c8-7ad6-b902-d25cfd626eb0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_01a0c545-51c8-76a1-835a-d5e65bac8bb1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_Goodwill_01a0c545-51c8-76a1-835a-d5e65bac8bb1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_PercentageOfConsolidatedNetSalesRepresentedBySalesOutsideUS_01a0c545-51c8-7db6-8231-fab14bf21899" xlink:href="cl-20260930.xsd#cl_PercentageOfConsolidatedNetSalesRepresentedBySalesOutsideUS"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_cl_PercentageOfConsolidatedNetSalesRepresentedBySalesOutsideUS_01a0c545-51c8-7db6-8231-fab14bf21899" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_PercentageOfConsolidatedNetSalesComingFromEmergingMarkets_01a0c545-51c8-7dc1-b063-2cb8aa007928" xlink:href="cl-20260930.xsd#cl_PercentageOfConsolidatedNetSalesComingFromEmergingMarkets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_cl_PercentageOfConsolidatedNetSalesComingFromEmergingMarkets_01a0c545-51c8-7dc1-b063-2cb8aa007928" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_01a0c545-51c8-74de-9dae-7ab290b6d2f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_RestructuringCosts_01a0c545-51c8-74de-9dae-7ab290b6d2f0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-728f-b623-7f5b28b072c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-728f-b623-7f5b28b072c1" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_01a0c545-51c8-7661-892b-104395e506eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_01a0c545-51c8-7661-892b-104395e506eb" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/SegmentInformationNarrativeDetails_1" xlink:type="simple" xlink:href="cl-20260930.xsd#SegmentInformationNarrativeDetails_1"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/SegmentInformationNarrativeDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7775-96e9-5b7dbd72bcdb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7775-96e9-5b7dbd72bcdb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7286-9397-07af59ba2f79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7775-96e9-5b7dbd72bcdb" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7286-9397-07af59ba2f79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_AsiaPacificSegmentMember_01a0c545-51c8-76e9-afcc-9ced32bb8f36" xlink:href="cl-20260930.xsd#cl_AsiaPacificSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-7286-9397-07af59ba2f79" xlink:to="loc_cl_AsiaPacificSegmentMember_01a0c545-51c8-76e9-afcc-9ced32bb8f36" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7101-8992-99fee05f0923_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7101-8992-99fee05f0923_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7fcd-bbea-f49828760163" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7101-8992-99fee05f0923" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7fcd-bbea-f49828760163" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_RussiaAndBelarusMember_01a0c545-51c8-7b9c-bc4a-16413913c1a4" xlink:href="cl-20260930.xsd#cl_RussiaAndBelarusMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7fcd-bbea-f49828760163" xlink:to="loc_cl_RussiaAndBelarusMember_01a0c545-51c8-7b9c-bc4a-16413913c1a4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7b42-a22b-76c222665cd7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7b42-a22b-76c222665cd7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7575-8ab5-3d8e70cdd426" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7b42-a22b-76c222665cd7" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7575-8ab5-3d8e70cdd426" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_01a0c545-51c8-7ef9-8d1c-c1e098fad88c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7575-8ab5-3d8e70cdd426" xlink:to="loc_us-gaap_SalesRevenueNetMember_01a0c545-51c8-7ef9-8d1c-c1e098fad88c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7908-80e7-f78efe12155a_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:to="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7908-80e7-f78efe12155a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-74ff-86f4-8a165b8b4a4d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7908-80e7-f78efe12155a" xlink:to="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-74ff-86f4-8a165b8b4a4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_01a0c545-51c8-77db-bbeb-4813ddc0f61f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-74ff-86f4-8a165b8b4a4d" xlink:to="loc_us-gaap_CorporateNonSegmentMember_01a0c545-51c8-77db-bbeb-4813ddc0f61f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7006-9c17-61a9e06ecd7c" xlink:to="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-74b5-9ef8-7891c8fb0924_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-74b5-9ef8-7891c8fb0924_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7fcc-9410-a34abd4eeb9f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_01a0c545-51c8-74b5-9ef8-7891c8fb0924" xlink:to="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7fcc-9410-a34abd4eeb9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-769e-be16-070a62645cb1" xlink:href="cl-20260930.xsd#cl_StrategicGrowthAndProductivityProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_01a0c545-51c8-7fcc-9410-a34abd4eeb9f" xlink:to="loc_cl_StrategicGrowthAndProductivityProgramMember_01a0c545-51c8-769e-be16-070a62645cb1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_01a0c545-51c8-771c-9f69-e9d4d0c189b0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_NumberOfOperatingSegments_01a0c545-51c8-771c-9f69-e9d4d0c189b0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_01a0c545-51c8-72d3-954d-2dec7a3277e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_NumberOfReportableSegments_01a0c545-51c8-72d3-954d-2dec7a3277e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_NumberOfGeographicallyReportableOperatingSegments_01a0c545-51c8-7ad6-b902-d25cfd626eb0" xlink:href="cl-20260930.xsd#cl_NumberOfGeographicallyReportableOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_cl_NumberOfGeographicallyReportableOperatingSegments_01a0c545-51c8-7ad6-b902-d25cfd626eb0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_01a0c545-51c8-76a1-835a-d5e65bac8bb1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_Goodwill_01a0c545-51c8-76a1-835a-d5e65bac8bb1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_PercentageOfConsolidatedNetSalesRepresentedBySalesOutsideUS_01a0c545-51c8-7db6-8231-fab14bf21899" xlink:href="cl-20260930.xsd#cl_PercentageOfConsolidatedNetSalesRepresentedBySalesOutsideUS"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_cl_PercentageOfConsolidatedNetSalesRepresentedBySalesOutsideUS_01a0c545-51c8-7db6-8231-fab14bf21899" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_PercentageOfConsolidatedNetSalesComingFromEmergingMarkets_01a0c545-51c8-7dc1-b063-2cb8aa007928" xlink:href="cl-20260930.xsd#cl_PercentageOfConsolidatedNetSalesComingFromEmergingMarkets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_cl_PercentageOfConsolidatedNetSalesComingFromEmergingMarkets_01a0c545-51c8-7dc1-b063-2cb8aa007928" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_01a0c545-51c8-74de-9dae-7ab290b6d2f0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestructuringCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_RestructuringCosts_01a0c545-51c8-74de-9dae-7ab290b6d2f0" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-728f-b623-7f5b28b072c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_LitigationSettlementExpense_01a0c545-51c8-728f-b623-7f5b28b072c1" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_01a0c545-51c8-7661-892b-104395e506eb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7243-9786-46915efce9b5" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_01a0c545-51c8-7661-892b-104395e506eb" xlink:type="arc" order="8"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/SegmentInformationScheduleofNetSalesandOperatingProfitbySegmentDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#SegmentInformationScheduleofNetSalesandOperatingProfitbySegmentDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/SegmentInformationScheduleofNetSalesandOperatingProfitbySegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7557-979d-20522f6a11b6" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:to="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7557-979d-20522f6a11b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7557-979d-20522f6a11b6_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7557-979d-20522f6a11b6" xlink:to="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7557-979d-20522f6a11b6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7a19-8a8b-6374d7f4f72d" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ConsolidationItemsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidationItemsAxis_01a0c545-51c8-7557-979d-20522f6a11b6" xlink:to="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7a19-8a8b-6374d7f4f72d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingSegmentsMember_01a0c545-51c8-7b7e-aed1-a389db93badc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingSegmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7a19-8a8b-6374d7f4f72d" xlink:to="loc_us-gaap_OperatingSegmentsMember_01a0c545-51c8-7b7e-aed1-a389db93badc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateNonSegmentMember_01a0c545-51c8-7a1a-b432-d028a3d7257d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CorporateNonSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidationItemsDomain_01a0c545-51c8-7a19-8a8b-6374d7f4f72d" xlink:to="loc_us-gaap_CorporateNonSegmentMember_01a0c545-51c8-7a1a-b432-d028a3d7257d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7160-a2fd-4312d4fd69ad" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7160-a2fd-4312d4fd69ad" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-7160-a2fd-4312d4fd69ad_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7160-a2fd-4312d4fd69ad" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-7160-a2fd-4312d4fd69ad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_01a0c545-51c8-76bd-86e0-0123d504491f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_01a0c545-51c8-7160-a2fd-4312d4fd69ad" xlink:to="loc_us-gaap_SegmentDomain_01a0c545-51c8-76bd-86e0-0123d504491f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_OralPersonalAndHomeCareMember_01a0c545-51c8-7c67-8a62-415588e16d46" xlink:href="cl-20260930.xsd#cl_OralPersonalAndHomeCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-76bd-86e0-0123d504491f" xlink:to="loc_cl_OralPersonalAndHomeCareMember_01a0c545-51c8-7c67-8a62-415588e16d46" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_HillsPetNutritionMember_01a0c545-51c8-737f-828d-558b6981f5bd" xlink:href="cl-20260930.xsd#cl_HillsPetNutritionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_01a0c545-51c8-76bd-86e0-0123d504491f" xlink:to="loc_cl_HillsPetNutritionMember_01a0c545-51c8-737f-828d-558b6981f5bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7637-9f98-0d420fd5e74f" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:to="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7637-9f98-0d420fd5e74f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7637-9f98-0d420fd5e74f_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7637-9f98-0d420fd5e74f" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7637-9f98-0d420fd5e74f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7e7a-b3d1-be27fe4cfcde" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_01a0c545-51c8-7637-9f98-0d420fd5e74f" xlink:to="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7e7a-b3d1-be27fe4cfcde" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NorthAmericaMember_01a0c545-51c8-7b05-b3c9-975dcf445c18" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_NorthAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7e7a-b3d1-be27fe4cfcde" xlink:to="loc_srt_NorthAmericaMember_01a0c545-51c8-7b05-b3c9-975dcf445c18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LatinAmericaMember_01a0c545-51c8-7808-83bd-369341f1a0b8" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_LatinAmericaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7e7a-b3d1-be27fe4cfcde" xlink:to="loc_srt_LatinAmericaMember_01a0c545-51c8-7808-83bd-369341f1a0b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EMEAMember_01a0c545-51c8-7285-8bdd-b928dc6d3f16" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EMEAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7e7a-b3d1-be27fe4cfcde" xlink:to="loc_us-gaap_EMEAMember_01a0c545-51c8-7285-8bdd-b928dc6d3f16" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaPacificMember_01a0c545-51c8-7c78-9bff-05736bc0695e" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_AsiaPacificMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_01a0c545-51c8-7e7a-b3d1-be27fe4cfcde" xlink:to="loc_srt_AsiaPacificMember_01a0c545-51c8-7c78-9bff-05736bc0695e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7f79-8dfc-7a9015cf4d7a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7f79-8dfc-7a9015cf4d7a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7f79-8dfc-7a9015cf4d7a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7f79-8dfc-7a9015cf4d7a" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7f79-8dfc-7a9015cf4d7a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7157-8241-d9728f0ed3b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_01a0c545-51c8-7f79-8dfc-7a9015cf4d7a" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7157-8241-d9728f0ed3b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_01a0c545-51c8-7b3e-acd3-9e591ea284c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_01a0c545-51c8-7157-8241-d9728f0ed3b3" xlink:to="loc_us-gaap_SalesRevenueNetMember_01a0c545-51c8-7b3e-acd3-9e591ea284c4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_01a0c545-51c8-762a-a99e-f863db211640" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_01a0c545-51c8-762a-a99e-f863db211640" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_01a0c545-51c8-762a-a99e-f863db211640_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_01a0c545-51c8-762a-a99e-f863db211640" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_01a0c545-51c8-762a-a99e-f863db211640_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_01a0c545-51c8-7c9a-b28a-cf8d72c70ebd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_01a0c545-51c8-762a-a99e-f863db211640" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_01a0c545-51c8-7c9a-b28a-cf8d72c70ebd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductConcentrationRiskMember_01a0c545-51c8-7c99-acd9-182301a25606" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProductConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_01a0c545-51c8-7c9a-b28a-cf8d72c70ebd" xlink:to="loc_us-gaap_ProductConcentrationRiskMember_01a0c545-51c8-7c99-acd9-182301a25606" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_01a0c545-51c8-72cd-b0d1-f447362fd67b" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_01a0c545-51c8-7512-906d-f89aa2266c8c" xlink:to="loc_srt_ProductOrServiceAxis_01a0c545-51c8-72cd-b0d1-f447362fd67b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-72cd-b0d1-f447362fd67b_default" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_01a0c545-51c8-72cd-b0d1-f447362fd67b" xlink:to="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-72cd-b0d1-f447362fd67b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-78ae-a9cf-f0bda1e4d0eb" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_01a0c545-51c8-72cd-b0d1-f447362fd67b" xlink:to="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-78ae-a9cf-f0bda1e4d0eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_OralCareMember_01a0c545-51c8-716e-8321-3f5424e84ba1" xlink:href="cl-20260930.xsd#cl_OralCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-78ae-a9cf-f0bda1e4d0eb" xlink:to="loc_cl_OralCareMember_01a0c545-51c8-716e-8321-3f5424e84ba1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_PersonalCareMember_01a0c545-51c8-7224-942d-6074272382d3" xlink:href="cl-20260930.xsd#cl_PersonalCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-78ae-a9cf-f0bda1e4d0eb" xlink:to="loc_cl_PersonalCareMember_01a0c545-51c8-7224-942d-6074272382d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_HomeCareMember_01a0c545-51c8-7b27-b423-481a36ad7ea0" xlink:href="cl-20260930.xsd#cl_HomeCareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-78ae-a9cf-f0bda1e4d0eb" xlink:to="loc_cl_HomeCareMember_01a0c545-51c8-7b27-b423-481a36ad7ea0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_HillsPetNutritionMember_01a0c545-51c8-76a3-a55e-781c7a71e702" xlink:href="cl-20260930.xsd#cl_HillsPetNutritionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_01a0c545-51c8-78ae-a9cf-f0bda1e4d0eb" xlink:to="loc_cl_HillsPetNutritionMember_01a0c545-51c8-76a3-a55e-781c7a71e702" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a0c545-51c8-706f-a9f5-af6d14f714aa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_01a0c545-51c8-706f-a9f5-af6d14f714aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_01a0c545-51c8-7dd9-974d-29885718d28b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_CostOfRevenue_01a0c545-51c8-7dd9-974d-29885718d28b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_01a0c545-51c8-78af-9048-ac58b14524c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_01a0c545-51c8-78af-9048-ac58b14524c8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCostAndExpenseOperating_01a0c545-51c8-727a-8cc3-60239c477003" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherCostAndExpenseOperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_OtherCostAndExpenseOperating_01a0c545-51c8-727a-8cc3-60239c477003" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_01a0c545-51c8-7620-b2bb-562d5d65ccb4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_OperatingIncomeLoss_01a0c545-51c8-7620-b2bb-562d5d65ccb4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_01a0c545-51c8-7083-9596-2624a9521636" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_01a0c545-51c8-7083-9596-2624a9521636" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_01a0c545-51c8-7f08-a4dd-edb57bf18644" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SegmentExpenditureAdditionToLongLivedAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_SegmentExpenditureAdditionToLongLivedAssets_01a0c545-51c8-7f08-a4dd-edb57bf18644" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_01a0c545-51c8-7d9f-8759-3d66d862d72d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_01a0c545-51c8-7809-b1a1-3b9ea70bd459" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_01a0c545-51c8-7d9f-8759-3d66d862d72d" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#FairValueMeasurementsandFinancialInstrumentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_01a0c545-51c8-73ac-83cd-e6cb72dc49c4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_01a0c545-51c8-7be3-9b68-2c1a90d3ac17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a0c545-51c8-73ac-83cd-e6cb72dc49c4" xlink:to="loc_us-gaap_DebtInstrumentTable_01a0c545-51c8-7be3-9b68-2c1a90d3ac17" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_01a0c545-51c8-7081-8028-754e281fb1f4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_01a0c545-51c8-7be3-9b68-2c1a90d3ac17" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_01a0c545-51c8-7081-8028-754e281fb1f4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a0c545-51c8-7081-8028-754e281fb1f4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_01a0c545-51c8-7081-8028-754e281fb1f4" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a0c545-51c8-7081-8028-754e281fb1f4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a0c545-51c8-7ac1-bcfe-b656a27d1e8a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_01a0c545-51c8-7081-8028-754e281fb1f4" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a0c545-51c8-7ac1-bcfe-b656a27d1e8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_01a0c545-51c8-7f9c-b2de-db34285ebdee" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_01a0c545-51c8-7ac1-bcfe-b656a27d1e8a" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_01a0c545-51c8-7f9c-b2de-db34285ebdee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_01a0c545-51c8-7a8f-bc6d-a683f86d5c63" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_01a0c545-51c8-7be3-9b68-2c1a90d3ac17" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_01a0c545-51c8-7a8f-bc6d-a683f86d5c63" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_01a0c545-51c8-7a8f-bc6d-a683f86d5c63_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_01a0c545-51c8-7a8f-bc6d-a683f86d5c63" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_01a0c545-51c8-7a8f-bc6d-a683f86d5c63_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_01a0c545-51c8-7a8d-803c-c1fea5e0f3a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_01a0c545-51c8-7a8f-bc6d-a683f86d5c63" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_01a0c545-51c8-7a8d-803c-c1fea5e0f3a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_01a0c545-51c8-767e-bb3d-448e441bc30b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_01a0c545-51c8-7a8d-803c-c1fea5e0f3a0" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_01a0c545-51c8-767e-bb3d-448e441bc30b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_01a0c545-51c8-7eab-bc4d-bb62dbe3565b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_01a0c545-51c8-767e-bb3d-448e441bc30b" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_01a0c545-51c8-7eab-bc4d-bb62dbe3565b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTermOfContract_01a0c545-51c8-709b-bd1d-7aa0ca8f9b33" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a0c545-51c8-73ac-83cd-e6cb72dc49c4" xlink:to="loc_us-gaap_DerivativeTermOfContract_01a0c545-51c8-709b-bd1d-7aa0ca8f9b33" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFairValue_01a0c545-51c8-73ae-ae1f-0dc0aae8aff4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a0c545-51c8-73ac-83cd-e6cb72dc49c4" xlink:to="loc_us-gaap_DebtInstrumentFairValue_01a0c545-51c8-73ae-ae1f-0dc0aae8aff4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_01a0c545-51c8-7f0b-bc55-0501e3386066" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_01a0c545-51c8-73ac-83cd-e6cb72dc49c4" xlink:to="loc_us-gaap_LongTermDebt_01a0c545-51c8-7f0b-bc55-0501e3386066" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofFairValueofDerivativeInstrumentsandOtherFinancialInstrumentsDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#FairValueMeasurementsandFinancialInstrumentsScheduleofFairValueofDerivativeInstrumentsandOtherFinancialInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofFairValueofDerivativeInstrumentsandOtherFinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_01a0c545-51c8-7448-93cc-cb04ba7e486d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_01a0c545-51c8-73d5-84bf-f3687a8fd7ac" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_01a0c545-51c8-7448-93cc-cb04ba7e486d" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_01a0c545-51c8-73d5-84bf-f3687a8fd7ac" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-789c-a68d-79e32d7ea64c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_01a0c545-51c8-73d5-84bf-f3687a8fd7ac" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-789c-a68d-79e32d7ea64c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-789c-a68d-79e32d7ea64c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-789c-a68d-79e32d7ea64c" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-789c-a68d-79e32d7ea64c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-77da-ad48-8a364df96181" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-789c-a68d-79e32d7ea64c" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-77da-ad48-8a364df96181" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-75ab-9637-f607164e880a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-77da-ad48-8a364df96181" xlink:to="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-75ab-9637-f607164e880a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_01a0c545-51c8-7876-926b-8dd14a850789" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-77da-ad48-8a364df96181" xlink:to="loc_us-gaap_CommodityContractMember_01a0c545-51c8-7876-926b-8dd14a850789" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_cl_DesignatedDerivativeInstrumentsAbstract_01a0c545-51c8-77ef-9aa2-5aba8b9899aa" xlink:href="cl-20260930.xsd#cl_DesignatedDerivativeInstrumentsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_01a0c545-51c8-7448-93cc-cb04ba7e486d" xlink:to="loc_cl_DesignatedDerivativeInstrumentsAbstract_01a0c545-51c8-77ef-9aa2-5aba8b9899aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_01a0c545-51c8-7474-a194-34b35ab01144" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cl_DesignatedDerivativeInstrumentsAbstract_01a0c545-51c8-77ef-9aa2-5aba8b9899aa" xlink:to="loc_us-gaap_DerivativeAssets_01a0c545-51c8-7474-a194-34b35ab01144" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_01a0c545-51c8-7392-8154-25146c2ad29b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssets_01a0c545-51c8-7474-a194-34b35ab01144" xlink:to="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_01a0c545-51c8-7392-8154-25146c2ad29b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_01a0c545-51c8-7fcc-b027-eba59a827270" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_cl_DesignatedDerivativeInstrumentsAbstract_01a0c545-51c8-77ef-9aa2-5aba8b9899aa" xlink:to="loc_us-gaap_DerivativeLiabilities_01a0c545-51c8-7fcc-b027-eba59a827270" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_01a0c545-51c8-7974-b443-08030d1aae34" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilities_01a0c545-51c8-7fcc-b027-eba59a827270" xlink:to="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_01a0c545-51c8-7974-b443-08030d1aae34" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosureAbstract_01a0c545-51c8-7998-883d-2031dc9aae17" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_01a0c545-51c8-7448-93cc-cb04ba7e486d" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosureAbstract_01a0c545-51c8-7998-883d-2031dc9aae17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecurities_01a0c545-51c8-73bc-a7dd-2586a6cc5215" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_MarketableSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentsFairValueDisclosureAbstract_01a0c545-51c8-7998-883d-2031dc9aae17" xlink:to="loc_us-gaap_MarketableSecurities_01a0c545-51c8-73bc-a7dd-2586a6cc5215" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgeAssetsAtFairValue_01a0c545-51c8-7277-bd3e-3c1f462d71d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueHedgeAssetsAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentsFairValueDisclosureAbstract_01a0c545-51c8-7998-883d-2031dc9aae17" xlink:to="loc_us-gaap_FairValueHedgeAssetsAtFairValue_01a0c545-51c8-7277-bd3e-3c1f462d71d2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgeLiabilitiesAtFairValue_01a0c545-51c8-74ef-8034-1852b787e646" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueHedgeLiabilitiesAtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentsFairValueDisclosureAbstract_01a0c545-51c8-7998-883d-2031dc9aae17" xlink:to="loc_us-gaap_FairValueHedgeLiabilitiesAtFairValue_01a0c545-51c8-74ef-8034-1852b787e646" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofNotionalValuesDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#FairValueMeasurementsandFinancialInstrumentsScheduleofNotionalValuesDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofNotionalValuesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-754d-a697-f835405f9b35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7637-af40-f4defa5151c6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-754d-a697-f835405f9b35" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7637-af40-f4defa5151c6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7610-8c69-eb5a0523fc54" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7637-af40-f4defa5151c6" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7610-8c69-eb5a0523fc54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-7610-8c69-eb5a0523fc54_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7610-8c69-eb5a0523fc54" xlink:to="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-7610-8c69-eb5a0523fc54_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-7591-b0aa-96ae63b25695" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7610-8c69-eb5a0523fc54" xlink:to="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-7591-b0aa-96ae63b25695" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_01a0c545-51c8-7001-9fb7-2d3ea19d3ad4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-7591-b0aa-96ae63b25695" xlink:to="loc_us-gaap_FairValueHedgingMember_01a0c545-51c8-7001-9fb7-2d3ea19d3ad4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-73e6-92eb-e2b2b7dfb172" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7637-af40-f4defa5151c6" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-73e6-92eb-e2b2b7dfb172" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-73e6-92eb-e2b2b7dfb172_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-73e6-92eb-e2b2b7dfb172" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-73e6-92eb-e2b2b7dfb172_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-71dc-a9f3-ed1d185676be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-73e6-92eb-e2b2b7dfb172" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-71dc-a9f3-ed1d185676be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-778b-97eb-e866cf784aaf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-71dc-a9f3-ed1d185676be" xlink:to="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-778b-97eb-e866cf784aaf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtMember_01a0c545-51c8-7d02-a652-dc5e1e46ded2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-71dc-a9f3-ed1d185676be" xlink:to="loc_us-gaap_DebtMember_01a0c545-51c8-7d02-a652-dc5e1e46ded2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommodityContractMember_01a0c545-51c8-7594-bea7-000ef0dbd5a2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommodityContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-71dc-a9f3-ed1d185676be" xlink:to="loc_us-gaap_CommodityContractMember_01a0c545-51c8-7594-bea7-000ef0dbd5a2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_01a0c545-51c8-7027-b1e2-9228adc6a90a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-754d-a697-f835405f9b35" xlink:to="loc_us-gaap_DerivativeNotionalAmount_01a0c545-51c8-7027-b1e2-9228adc6a90a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofGainLossonHedgesRecognizedinStatementsofIncomeDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#FairValueMeasurementsandFinancialInstrumentsScheduleofGainLossonHedgesRecognizedinStatementsofIncomeDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofGainLossonHedgesRecognizedinStatementsofIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-7deb-b14e-f93c9be15578" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7458-abd2-fc7186aed3e2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-7deb-b14e-f93c9be15578" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7458-abd2-fc7186aed3e2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-79ad-b695-b5e40ac226e8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7458-abd2-fc7186aed3e2" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-79ad-b695-b5e40ac226e8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-79ad-b695-b5e40ac226e8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-79ad-b695-b5e40ac226e8" xlink:to="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-79ad-b695-b5e40ac226e8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-749e-8216-2ac1bb1fb679" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-79ad-b695-b5e40ac226e8" xlink:to="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-749e-8216-2ac1bb1fb679" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueHedgingMember_01a0c545-51c8-70e6-8b01-b6f61fb41c0c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-749e-8216-2ac1bb1fb679" xlink:to="loc_us-gaap_FairValueHedgingMember_01a0c545-51c8-70e6-8b01-b6f61fb41c0c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7f8d-9b27-f8a950d8a721" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7458-abd2-fc7186aed3e2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7f8d-9b27-f8a950d8a721" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-7f8d-9b27-f8a950d8a721_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7f8d-9b27-f8a950d8a721" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-7f8d-9b27-f8a950d8a721_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-741f-99cc-cd6ecda0d39a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7f8d-9b27-f8a950d8a721" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-741f-99cc-cd6ecda0d39a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-7658-b53c-945e86353694" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-741f-99cc-cd6ecda0d39a" xlink:to="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-7658-b53c-945e86353694" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_01a0c545-51c8-773f-843e-7b2a264a9892" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-7deb-b14e-f93c9be15578" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnFairValueHedgingInstruments1_01a0c545-51c8-773f-843e-7b2a264a9892" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_01a0c545-51c8-7e58-9f0d-33de3cc2a145" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-7deb-b14e-f93c9be15578" xlink:to="loc_us-gaap_ChangeInUnrealizedGainLossOnHedgedItemInFairValueHedge1_01a0c545-51c8-7e58-9f0d-33de3cc2a145" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofGainLossIncludedinOCIDetails" xlink:type="simple" xlink:href="cl-20260930.xsd#FairValueMeasurementsandFinancialInstrumentsScheduleofGainLossIncludedinOCIDetails"/>
  <link:definitionLink xlink:role="http://www.colgate.com/role/FairValueMeasurementsandFinancialInstrumentsScheduleofGainLossIncludedinOCIDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-7c0b-ab17-54563292eeb3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7bb8-acb4-bc6ea46bbcb2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-7c0b-ab17-54563292eeb3" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7bb8-acb4-bc6ea46bbcb2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7c68-bcee-50086e189b35" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7bb8-acb4-bc6ea46bbcb2" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7c68-bcee-50086e189b35" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-7c68-bcee-50086e189b35_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7c68-bcee-50086e189b35" xlink:to="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-7c68-bcee-50086e189b35_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-76ed-9338-4bfdbb00b068" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_01a0c545-51c8-7c68-bcee-50086e189b35" xlink:to="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-76ed-9338-4bfdbb00b068" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_01a0c545-51c8-7d48-9624-5672edd66ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_01a0c545-51c8-76ed-9338-4bfdbb00b068" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_01a0c545-51c8-7d48-9624-5672edd66ce8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7394-bf43-2ff1ff52d536" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_01a0c545-51c8-7bb8-acb4-bc6ea46bbcb2" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7394-bf43-2ff1ff52d536" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-7394-bf43-2ff1ff52d536_default" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7394-bf43-2ff1ff52d536" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-7394-bf43-2ff1ff52d536_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-79dd-8ee6-576140b7a696" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_01a0c545-51c8-7394-bf43-2ff1ff52d536" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-79dd-8ee6-576140b7a696" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-7c89-9552-5760885552f2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-79dd-8ee6-576140b7a696" xlink:to="loc_us-gaap_ForeignExchangeContractMember_01a0c545-51c8-7c89-9552-5760885552f2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtMember_01a0c545-51c8-7fdc-82b5-5f6f8467aabe" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_01a0c545-51c8-79dd-8ee6-576140b7a696" xlink:to="loc_us-gaap_DebtMember_01a0c545-51c8-7fdc-82b5-5f6f8467aabe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SummaryOfNetInvestmentHedgeActivityAbstract_01a0c545-51c8-74a6-b2ff-7f8fbc5aed5a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SummaryOfNetInvestmentHedgeActivityAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_01a0c545-51c8-7c0b-ab17-54563292eeb3" xlink:to="loc_us-gaap_SummaryOfNetInvestmentHedgeActivityAbstract_01a0c545-51c8-74a6-b2ff-7f8fbc5aed5a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_01a0c545-51c8-7a18-adf0-6c33bb79dbcb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SummaryOfNetInvestmentHedgeActivityAbstract_01a0c545-51c8-74a6-b2ff-7f8fbc5aed5a" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_01a0c545-51c8-7a18-adf0-6c33bb79dbcb" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/srt/2026/elts/srt-roles-2026.xsd#eedm1"/>
  <link:definitionLink xlink:role="http://fasb.org/srt/role/srt-eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="loc_us-gaap_OtherAssetsCurrent" xlink:type="arc" order="101"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAbstract" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent" xlink:type="arc" order="31"/>
  </link:definitionLink>
</link:linkbase>
